I-Graphene Antibacterial Mechanism kanye Nesicelo

Imbobo yomlomo iyi-microecosystem eyinkimbinkimbi enezinhlobo ezingaphezu kuka-23,000 zamagciwane ayikoloni.Ezimweni ezithile, lawa mabhaktheriya angabangela ngokuqondile izifo zomlomo futhi abe nomthelela nempilo yonke. Kodwa-ke, ukusetshenziswa kwama-antibiotic kuletha izinkinga ezihlukahlukene, okuhlanganisa ukuwohloka kwezidakamizwa ngokushesha, ukukhululwa, nokuthuthukiswa kokungazweli kwama-antibiotic. Eminyakeni yakamuva, ucwaningo luye lwagxila ekuthuthukisweni kwezinto eziyinhlanganisela ezinezakhiwo ezinhle kakhulu zokulwa namagciwane kusetshenziswa ama-nanomaterials. Njengamanje, izinto zokulwa namagciwane ezisekelwe ku-nanosilver ion kanye nezinto zokulwa namagciwane ezisekelwe ku-graphene zivame ukusetshenziswa emakethe.Kulesi sihloko, sizokwethula indlela ye-graphene antibacterial kanye nokusetshenziswa embonini yesixubho.

 

I-Graphene iyi-carbon nanomaterial enezinhlangothi ezimbili eyakhiwe ama-athomu ekhabhoni ahlelwe nge-hexagonal lattice ene-sp2 hybridized orbitals.Okuphuma kuyo kuhlanganisa i-graphene (G), i-graphene oxide (GO), kanye ne-graphene oxide (rGO) encishisiwe. Zinezinhlaka eziyingqayizivele zamakhemikhali angaphezulu kwezinhlangothi ezintathu kanye nezakhiwo ezibukhali zonqenqema lomzimba.Ucwaningo lubonise izici ezivelele zokulwa namagciwane kanye nokuvumelana kwe-graphene kanye nokuphuma kwayo. Ngaphezu kwalokho, zisebenza njengabathwali abafanelekile bama-antimicrobial, okubenza bathembise kakhulu ukusetshenziswa okuhlukahlukene emikhakheni ye-antimicrobial yomlomo.

Izinzuzo zegraphene izinto zokulwa namagciwane

1. Ukuphepha Nobungani Bendawo, Okungeyona ubuthi: Ukusetshenziswa isikhathi eside kwe-nanosilver kungaphakamisa ukukhathazeka kokuphepha ngenxaukunqwabelana okungenzeka kanye nokufuduka. Ukugcwala okuphezulu kwesiliva kungaba yingozi kakhulu kubantu nasezilwaneni ezincelisayo, njengoba kungangena emitochondria, imibungu, isibindi, izinhlelo zokujikeleza kwegazi, nezinye izingxenye zomzimba ngokuphefumula. Ucwaningo luye lwabonisa ukuthi izinhlayiya ze-nanosilver zibonisa ubuthi obunamandla uma kuqhathaniswa namanye ama-nanoparticles ensimbi njenge-aluminium negolide. Ngenxa yalokhu, i-European Union igcina isimo sokuqapha mayelana nokusetshenziswa kwe-nanosilver antimicrobial materials.Ngokungqubuzanayo, izinto ezilwa namagciwane ezisekelwe ku-graphene zisebenzisa izindlela eziningi zokuvala inzalo emzimbeni, njengokuthi "imimese ye-nano." Bangakwazi ukubhubhisa ngokuphelele futhi bavimbele ukukhula kwamagciwanengaphandle kobuthi bamakhemikhali. Lezi zinto zihlangana ngaphandle komthungo nezinto ze-polymer, ukuze kuqinisekisweakukho ukuhlukaniswa kwezinto ezibonakalayo noma ukufuduka. Ukuphepha nokuzinza kwezinto ezisekelwe ku-graphene kuqinisekiswe kahle. Isibonelo, ekusetshenzisweni komkhiqizo ongokoqobo, amafilimu/izikhwama ze-graphene-based PE (i-polyethylene) okulondoloza ukudla athole isitifiketi sokuthobelana nebanga lokudla ngokoMthetho (EU) 2020/1245 ku-European Union.
2. Ukuzinza Kwesikhathi Eside: Izinto ezisekelwe ku-graphene zibonisa ukuzinza nokuqina okuphezulu, ukuhlinzekaumphumela we-antimicrobial ohlala isikhathi eside iminyaka engaphezu kwe-10. Lokhu kuqinisekisa ukuthi izakhiwo zabo ze-antimicrobial zihlala zisebenza isikhathi eside sokusetshenziswa, okuzenza zifanelekele ukusetshenziswa kwesikhathi eside emikhiqizweni yokuhlanzeka ngomlomo.
3. I-Biocompatibility Nokuphepha:I-Graphene, njengezinto ezisekelwe ku-carbon-dimensional ezimbili, ibonisa ukuhambisana okuhle kakhulu kwe-biocompatibility nokuphepha. Ihambisana nezinhlobonhlobo zezinto ezisekelwe ku-resin futhi ingasetshenziswa ngokuphepha emikhiqizweni yokunakekelwa komlomo ngaphandle kokubangela noma yimiphi imiphumela emibi ezicutshini zomlomo noma impilo yonke.
4. Umsebenzi we-Broad-Spectrum:Izinto ezisuselwa ku-graphene zibonisa umsebenzi we-antimicrobial obanzi,ekwazi ukukhomba anhlobonhlobo amagciwane, okuhlanganisa kokubili izinhlobo ze-Gram-positive kanye ne-Gram-negative. BabonisileAmazinga e-antibacterial angu-99.9%ngokumelene ne-Escherichia coli, i-Staphylococcus aureus, ne-Candida albicans. Lokhu kubenza baguquguquke futhi basebenze ezimeni ezahlukahlukene zempilo yomlomo.

 

I-graphene antibacterial mechanism imi kanje:

I-antibacterial mechanism ye-grapheneicutshungulwe kabanzi yiqembu elisebenzisanayo lamazwe ngamazwe. Kubandakanya abacwaningi abavela eChinese Academy of Sciences, IBM Watson Research Center, kanye neColumbia University. Benze inqubekelaphambili ebalulekile ekutadisheni izindlela zamangqamuzana zokusebenzelana phakathi kwe-graphene ne-bacterial cell membranes. Amaphepha akamuva ngalesi sihloko ashicilelwe kujenali ethi "Nanotechnology Yemvelo."

Ngokocwaningo lweqembu, i-graphene inamandla okuphazamisa ulwelwesi lwamaseli ebhaktheriya, okuholela ekuvuzeni kwezinto ezingaphakathi kweseli nokufa kwebhaktheriya. Lokhu kutholakala kuphakamisa ukuthi i-graphene ingase isebenze “njengemithi elwa namagciwane” engazweli. Ucwaningo luphinde lwembule ukuthi i-graphene ayizifaki nje kuphela kulwelwesi lwamangqamuzana ebhaktheriya, ibangele ukusikeka, kodwa futhi ikhipha ama-molecule e-phospholipid ngokuqondile kulwelwesi, ngaleyo ndlela iphazamise ukwakheka kwe-membrane futhi ibulale amagciwane. Ukuhlolwa kwe-electron microscopy kunikeze ubufakazi obuqondile bezakhiwo ezingenalutho ezibanzi kulwelwesi lwamaseli ebhaktheriya ngemva kokuxhumana ne-graphene ene-oxidized, esekela izibalo zethiyori. Le nto yokukhipha i-lipid molecule kanye nokuphazamiseka kwe-membrane inikeza indlela entsha yamangqamuzana yokuqonda i-cytotoxicity nomsebenzi we-antibacterial wama-nanomaterials. Izophinde yenze ucwaningo olwengeziwe mayelana nemiphumela yebhayoloji ye-graphene nanomatadium kanye nokusetshenziswa kwayo ku-biomedicine.

 

Ukusetshenziswa kwe-graphene antibacterial embonini yesixubho:

 

Ngenxa yezinzuzo ezingenhla zezinto ezihlanganisiwe ze-graphene, indlela yokulwa namagciwane ye-graphene nokusetshenziswa kwayo kudonse isasasa elikhulu kubacwaningi nochwepheshe bezimboni ezihlobene.

Izixubho ze-Graphene antibacterial, yethulwe nguIqembu le-MARBON, sebenzisa ama-bristles aklanywe ngokukhethekile enziwe ngezinto ze-graphene nanocomposite. Ngakho-ke ingavimbela ngokuphumelelayo ukukhula nokukhiqizwa kwamagciwane, ngaleyo ndlela kunciphise ingozi yezifo zomlomo.

Ama-bristles athambile kodwa aqinile, avumela ukuhlanzwa kahle kwamazinyo nezinsini kuyilapho kuvikela uqweqwe lwawo nempilo yezinsini. Ibhulashi lamazinyo liphinde libe nedizayini yesibambo se-ergonomic esihlinzeka ngokubamba okunethezekile nokusetshenziswa okulungile.

Sikholelwa ngokuqinile ukuthi lesi sixubho se-antibacterial sizoletha ukunakekelwa komlomo okukhethekile. Ingakwazi ukususa ngempumelelo uqweqwe lwamazinyo kanye nemfucumfucu yokudla. Ukwengeza, inikeza isivikelo se-antibacterial esihlala isikhathi eside, siqinisekisa ukuthi umlomo wakho uhlala uhlanzekile futhi unempilo.

 

 

Isiphetho:

Izixubho ezilwa namagciwane e-graphene zimelela intuthuko yakamuva ekusetshenzisweni kwezinto ze-graphene emkhakheni we-antibacterial. Ngamandla azo amakhulu, izixubho ze-graphene antibacterial zihlelelwe ukuguqula ukunakekelwa komlomo, zinikeze abantu ulwazi olunempilo nolunethezekile lokunakekelwa komlomo. Njengoba ucwaningo lwezinto ze-graphene luqhubeka, izixubho ze-graphene antibacterial zizodlala indima ekhulayo ekuthuthukiseni impilo yomlomo kanye nokuphila kahle.